A very, very interesting historical tidbit is that, in 7 of Duke's 9 non-1-seed flameouts, the best player on the opponent had double letters in his name. For example, Russ Smith and CJ McCollum. This still applies even if you replace Dante Cunningham with Scottie Reynolds as the best player on 2009 Villanova.
This is statistically significant, as only 23.8% of players in Division I since 2003 have had double letters in their preferred names.
Your mind may be racing right now, so I will save you the trouble: UNC's projected best player in the NCAA Tournament is Joel Berry. You may believe Duke is in the clear against their widely predicted 3-seed, MSU, but the reality is that MSU's best player this season has been neither of their best draft prospects - Miles Bridges or Jaren Jackson - but, rather, Cassius Winston.